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Rocio Castro Seoane on Muck Rack

Rocio Castro Seoane

As seen in: Nature, Cell Reports
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Articles

TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment

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By Danae Fonseca, Giuseppe Pisanelli, Rocio Castro Seoane, Rocío Seoane, Lisa Miorin, Adolfo Garcia-Sastre
| Cell Reports Verified
Keywords TRIM65 IRF3 innate immunity chromatin IFNβ promoter K6-linked ubiquitination Research topic(s) CP: Immunology Introduction Eukaryotes have evolved an intricate network of cellular defense mechanisms against a variety of pathogens, including viruses. The innate cellular response to viral infection includes the activation of several signal transduction cascades that are tightly regulated with the final goal of protecting the host against virus infection.
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Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

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By Greg Crawford, Mark Hayes, Sophie Ward, Rocio Castro Seoane
| Nature Verified
(a) Quantitative RT-PCR analysis of Rae-1 relative to cyclophylin in skin epithelial cells (n=3) and (b-c) FACS analysis of γH2AX, as a measure of ds-DNA breaks, in skin epithelial cells (n=4), at indicated time-points after topical exposure to a single dose of DMBA to the dorsal ear skin of wild-type FVB mice. UT = untreated (n=4-5). (b) Representative FACS plots of γH2AX staining in CD45- epidermal cells.
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