Linda Brady

Editor’s summary Acute graft-versus-host disease (aGVHD) is a frequent complication of allogeneic hematopoietic stem cell transplantation. Alloreactive T cells have been implicated in this disease but do not explain the range of clinical outcomes. Azulay et al. generated single-cell spatial maps of duodenal and colonic tissue from healthy individuals and patients with aGVHD based on multiplexed imaging of 40 proteins to characterize cellular dynamics.

Abstract Decades of research on biomarker identification and integration in Alzheimer’s disease (AD) have helped to advance biologically driven disease models, disease subtypes, and disease-modifying treatments.

Abstract NIMH’s mission is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. New imaging techniques hold great promise for improving our understanding of the pathophysiology of mental illnesses, stratifying patients for treatment selection, and developing a personalized medicine approach.