Rocky M. Barilla

Abstract Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is considerably lacking. Here, we characterized a primary enteric sensory neuron (PSN) subset producing the neuropeptides neuromedin U (NMU) and calcitonin gene-related peptide β (CGRPβ) and coexpressing receptors for the type 2 cytokines interleukin-4 (IL-4) and IL-13.

Correction to: Nature https://doi.org/10.1038/s41586-023-06231-0 Published online 21 June 2023 In the version of the article initially published, there was an error in Fig. 3e where a representative flow plot from the anti-Tim-1 + anti-PD-1 group (combination treatment) was inadvertently presented in place of the isotype control group flow plot and has been corrected in the HTML and PDF versions of the article. The original and corrected Fig. 3e are shown below as Fig. 1.

Abstract The balance between T helper type 1 (TH1) cells and other TH cells is critical for antiviral and anti-tumour responses1,2,3, but how this balance is achieved remains poorly understood. Here we dissected the dynamic regulation of TH1 cell differentiation during in vitro polarization, and during in vivo differentiation after acute viral infection.