Ayshwarya Subramanian

Abstract Microglia are the resident immune cells in the brain and have pivotal roles in neurodevelopment and neuroinflammation1,2. This study investigates the function of the immune-checkpoint molecule TIM-3 (encoded by HAVCR2) in microglia. TIM-3 was recently identified as a genetic risk factor for late-onset Alzheimer’s disease3, and it can induce T cell exhaustion4. However, its specific function in brain microglia remains unclear.

Abstract The balance between T helper type 1 (TH1) cells and other TH cells is critical for antiviral and anti-tumour responses1,2,3, but how this balance is achieved remains poorly understood. Here we dissected the dynamic regulation of TH1 cell differentiation during in vitro polarization, and during in vivo differentiation after acute viral infection.

Keywords diabetic kidney disease single-cell transcriptomics macrophage TREM2 inflammation immune myeloid Research topic(s) CP: Immunology Introduction Diabetic kidney disease (DKD) is a serious complication of diabetes in the kidneys and the leading cause of chronic kidney diseases, affecting 400 million patients worldwide.1,2 Further, the high prevalence of obesity is closely linked to the increasing incidence of chronic diseases such as type 2 diabetes (T2D),3 hypertension,4 and kidney...