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Rodin CHERMAT

As seen in: Royal Society of Chemistry
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Articles

Hypoxic-Core (HyCo) Spheroids Recapitulate Hallmarks of Clinical Hypoxia: A Simple Chip-Based Method for Translational Oncology

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By Elena Refet-Mollof, Rodin CHERMAT, Thomas Gervais, Julie Lafontaine
| biorxiv.org
Abstract Hypoxia influences the biology and response of cancers. No user-friendly device allows the study of hypoxia on highly-controlled clinically-relevant tumor models. Here, we describe how hypoxic-core (HyCo) spheroids generated using our unique non-perfused microfluidic device recapitulate key clinical hallmarks of hypoxia in vitro. Our PDMS-made system can generate up to 240 spheroids naturally exhibiting a diffusion-driven hypoxic core in only 4 days, here from two sarcoma cell lines.
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Brachytherapy on-a-chip: a clinically-relevant approach for radiotherapy testing in 3d biology

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By Rodin CHERMAT, Polytechnique Montréal, Elena Refet-Mollof, Yuji Kamio
| Royal Society of Chemistry Verified
Brachytherapy on-a-chip: a clinically-relevant approach for radiotherapy testing in 3d biology† We describe the first microfluidic device for in vitro testing of brachytherapy (BT), with applications in translational cancer research.
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Radiotherapy on-chip: microfluidics for translational radiation oncology

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By Rodin CHERMAT, Polytechnique Montréal, Maryam Ziaee, David Mak
| Royal Society of Chemistry Verified
Radiotherapy on-chip: microfluidics for translational radiation oncology Rodin Chermat,*ab Maryam Ziaee,ab David Y.
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