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Rodrigo Barderas on Muck Rack

Rodrigo Barderas

As seen in: Nature, Frontiers, The Journal of Immunology
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Articles

Cannabinoid CB 2 receptor drives trastuzumab resistance and predicts durable anti-HER2 response

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By Marta Seijo-Vila, Sandra Blasco-Benito, Isabel Tundidor, Maria Rubert-Hernandez, Ana Montero-Calle, Rodrigo Barderas, Laura E. Kilpatrick, Simon R. Platt, Noemi Karsai, Deborah Gomez-Dominguez, Ignacio de Castro Verified, Carmen González-Lois, Antonio J. Sánchez-López, Belén Almoguera Pérez-Cejuela, Luis Manso, Sandra Zazo, Noemi López-Ejeda, Nuria G Martínez-Illescas, María Salazar-Roa, Sonia Castillo-Lluva, Stephen Hill, Manuel Guzman, Eduardo Pérez-Gómez, Cristina Sanchez Verified, Cristina Sánchez, Sofía A. Balsinde, Isabel Philps, Olga M. Antón, Diego García-Fresnadillo, Gala Silvestre-Egea, Esther Ramírez-Medina, Francisco Palomino-Duque, María Turienzo-Durán
| Nature Verified
Abstract Acquired or innate lack of response to standard HER2-targeted therapies remains a clinical issue in patients with HER2-positive breast cancer. Here, we investigated the role of the cannabinoid CB2 receptor (CB2R) in trastuzumab resistance. In human breast cancer samples, a decreased expression of HER2-CB2R heterodimers following neoadjuvant treatment, due to CB2R downregulation, was linked to poor long-term outcomes.
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Neurochondrin drives colorectal cancer progression by modulating the PODXL–Ezrin axis and mitochondrial function

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By María Garranzo-Asensio, Ana Montero-Calle, Javier Velázquez-Gutiérrez, Susana Molina, Jana Dziaková, Carmen Poves, Ana Ramírez de Molina, Javier Martinez-Useros, María Jesús Fernández-Aceñero, Rubén A. Bartolomé Verified, Rodrigo Barderas, Elisa Carral-Ibarra, Marta Gómez de Cedrón, Rodrigo Sanz-López
| Nature Verified
Abstract Neurochondrin (NCDN) has been recently identified as overexpressed in liver metastatic colorectal cancer (CRC) cells compared to poorly metastatic isogenic counterparts. While its cellular function and role in cancer and CRC remain unknown, patient survival data indicate that elevated NCDN levels are associated with poor prognosis.
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Precision-Engineered Nano-Electrospray Emitters Enhance Ionization Efficiency for Trap-Assisted Direct Infusion Mass Spectrometry: Application in Plasma Alzheimer’s Disease Proteomics

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By Ana Montero-Calle, Daniel Lopez-Ferrer, Rodrigo Barderas
| dx.doi.org
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