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Roey Baror on Muck Rack

Roey Baror

As seen in: Cell Press
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Articles

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

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By Björn Neumann, Chao Zhao, Roey Baror
| Cell Press Verified
Highlights • Aged OPCs fail to respond to differentiation signals • Aged OPCs acquire many of the hallmarks of cell aging • Fasting and the fasting mimetic metformin rejuvenate poor remyelination in aged rodents • Metformin reverses age-related changes, making OPCs respond to differentiation factors Summary The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS).
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