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Articles

The immunological profile of RC17 hESC-derived dopaminergic neural progenitor cells in vitro: Implications for the STEM-PD clinical trial

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By Annabel J Curle, Shaline V Fazal, Shamma Qarin, Xiaoling He, Roger Barker, Joanne Jones, Athena Stamper, Venkat Pisupati
| Stem Cell Reports Verified
Results First, we confirmed successful differentiation of RC17 hESC to mesDAp using the Nolbrant et al. protocol, as used in the STEM-PD trial.
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Single-cell transcriptomics identifies chondrocyte differentiation dynamics in vivo and in vitro

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By John Lawrence, Steven Woods, Kenny Roberts, Dinithi Sumanaweera, Petra Balogh, Alexander Predeus, Peng He, Krzysztof Polanski, Elena Prigmore, Elizabeth Tuck, Lira Mamanova, Di Zhou, Simone Webb, Laura Jardine, Xiaoling He, Roger Barker, Muzlifah Haniffa, Adrienne M. Flanagan, Matthew Young Verified, Sam Behjati, Omer A. Bayraktar, Susan J Kimber, Sarah A Teichmann
| Cell Press Verified
Keywords cartilage single-cell RNA sequencing skeletal development in vitro chondrogenesis Introduction Large-scale single-cell profiling studies have improved our understanding of the cellular composition of multiple organ systems.1 These efforts extend to human development, with profiles of different systems across developmental time providing insight into the origins of a range of diseases.2,3 This knowledge promises to improve the fidelity of in vitro organoid systems, providing both a...
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