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Roja Baruwal on Muck Rack

Roja Baruwal

As seen in: Nature, Cell Reports
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Articles

Mesenchymal stromal/stem cells in tumour initiation, progression and therapy

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By Geyon L. Garcia, Roja Baruwal, Swathi Suresh, Angelina Li, Huda I. Atiya, Lan G Coffman, Ananya Kapur Britt
| Nature Verified
Abstract The expanding study of mesenchymal stromal/stem cells (MSC) in cancer has amounted to a growing understanding of their underlying biology in malignant and non-malignant settings. In addition to supporting homeostasis in nearly all normal tissues, MSCs also serve as stromal support for a diverse set of malignancies, the most studied being ovarian, breast, brain, blood and colorectal cancers.
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Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer

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By Leonard G. Frisbie, Catherine Pressimone, Emma Dyer, Roja Baruwal
| Cell Reports Verified
Highlights • CA-MSCs donate mitochondria to ovarian cancer cells with low endogenous mitochondria • Mitochondrial donation enhances cancer cell proliferation, chemoresistance, and OXPHOS • Donated mito-to-nuclear signaling drives ANGPTL3 secretion, which increases tumor cell growth • Mito donation enhances metastasis and clonal heterogeneity in vivo Summary Ovarian cancer is characterized by early metastatic spread.
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