Rona Roverts

Abstract Outer membrane vesicle (OMV)-based vaccines elicit strong immune responses and have emerged as a versatile platform for targeting multiple pathogens, yet the mechanisms underlying their efficacy remain incompletely understood. Here, we investigated the early immune response following intranasal administration of an OMV-based pneumococcal vaccine candidate in mice.

Abstract Despite the enormous significance of malaria parasites for global health, some basic features of their ultrastructure remain obscure. Here, we apply high-resolution volumetric electron microscopy to examine and compare the ultrastructure of the transmissible male and female sexual blood stages of Plasmodium falciparum as well as the more intensively studied asexual blood stages revisiting previously described phenomena in 3D.

Abstract Organs-on-a-chip are of increasing interest for studying tissue development in health and disease. In the past years, platforms have been developed to analyze developmental biological processes by light microscopy and biochemical assays. While these show great potential for pharmaceutical applications, retrieving ultrastructural information about microtissues remains challenging.