Rong Tian, MD, PhD

Versatile polyphenolic platforms in regulating cell biology Huan Cao,a Lei Yang,a Rong Tian,a Haoxing Wu, b Zhipeng Gu*a and Yiwen Li *a Abstract Polyphenolic materials are a class of fascinating and versatile bioinspired materials for biointerfacial engineering.

Introduction Since the introduction of anthracyclines in the 1960s, the risk of anthracycline-induced cardiotoxicity (AIC) has limited its use in both adult and pediatric cancers (1). Approximately 23% of long-term survivors of pediatric cancers have an abnormal left ventricular ejection fraction (LVEF) 4 to 20 years post-anthracycline exposure (2), suggesting that myocardial damage is long-lasting and persistent.

Dietary supplementation with NAD+ precursors or ketone esters has been shown to improve mitochondrial function in preclinical models of heart failure with either reduced or preserved ejection fraction. Both supplementation approaches hold promise but are in the early stages of development as clinical therapies for heart failure. Access options Subscribe to Journal Get full journal access for 1 year $59.00 only $4.92 per issue All prices are NET prices. VAT will be added later in the checkout.