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Rosalin J. Simpson

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Articles

MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance - Nature

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By Mark White, Megan Mills, Kathryn L. Gilroy, Yourae Hong, Lucas B. Zeiger, Susanti Susanti, Rachel A. Ridgway, Lucile Grzesiak, Raheleh Amirkhah, Catriona A. Ford, Nikola Vlahov, Hannah Tovell, Leah Officer-Jones, Arafath K. Najumudeen, Alexander Raven, Nadia Nasreddin, Ekansh Chauhan, Colin Nixon, Rene Jackstadt, Janet Graham, Crispin Miller, Sarah Ross, Simon T. Barry, Richard Wilson, John Le Quesne, Philip Dunne, Sabine Tejpar, Simon J. Leedham, Andrew Campbell, Laura M. Millett, Rosalin J. Simpson, Amelia Ligeza, Ayse S. Yazgili, Catherine Ficken, Rachel Pennie, Andrew S. Papanastasiou, Vivienne Morrison, Valeria Pavet
| Nature Verified
Abstract The colorectal epithelium is rapidly renewing, with remarkable capacity to regenerate following injury. In colorectal cancer (CRC), this regenerative capacity can be co-opted to drive epithelial plasticity. While oncogenic MAPK signalling in CRC is common, with frequent mutations of both KRAS (40-50%) and BRAF (10%)1, inhibition of this pathway typically drives resistance clinically.
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MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance

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By Mark White, Megan Mills, Laura M. Millett, Kathryn L. Gilroy, Yourae Hong, Lucas B. Zeiger, Rosalin J. Simpson, Shania M Corry, Amelia Ligeza, Susanti Susanti, Rachel A. Ridgway, Ayse S. Yazgili, Lucile Grzesiak, Raheleh Amirkhah, Catriona A. Ford, Nikola Vlahov, Hannah Tovell, Leah Officer-Jones, Catherine Ficken, Rachel Pennie, Arafath K. Najumudeen, Alexander Raven, Nadia Nasreddin, Ekansh Chauhan, Andrew S. Papanastasiou, Colin Nixon, Vivienne Morrison, Rene Jackstadt, Janet Graham, Crispin Miller, Sarah Ross, Simon T. Barry, Valeria Pavet, Richard Wilson, John Le Quesne, Philip Dunne, Sabine Tejpar, Simon J. Leedham, Andrew Campbell, Owen J. Sansom
| Flipboard
Sleep Deprivation: Can Sleeping Less Than 7 Hours Fuel Obesity, Diabetes And Lead To Early Death? Check What Experts Say Sleep Deprivation: If you think skipping sleep is harmless, it may be time for a reality check. Many of us cut our nights short because of work, …
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