Skip to main content
Simon T. Barry on Muck Rack

Simon T. Barry

As seen in: Color Research & Application, Nature, Wiley Online Library, MDPI, Taylor & Francis Online, Flipboard, Science Magazine, Cell Press, Netflix Life, News Lanes and
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Simon T.

Contact Simon T., search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Harnessing myeloid cell plasticity for cancer therapy

|
By Emilio Sanseviero, Simon T. Barry, Dmitry I Gabrilovich
| Nature Verified
Abstract Myeloid cells have a multifaceted role in cancer, promoting tumor progression through angiogenesis, metastasis and immune suppression, as well as stimulating antitumor immunity. Traditionally, this dual functionality was attributed to cell heterogeneity, but it appears that myeloid cell plasticity is a more fundamental cancer trait.
Open in Who Shared Issue with article?

Probing intratumoral metabolic compartmentalisation in a patient with fumarate hydratase-deficient renal cancer using clinical hyperpolarised 13C-MRI and mass spectrometry imaging | Communications Medicine

|
By Ines Horvat-Menih, James Denholm, John Gallon, Andrew Gill, Andrew Priest, Simon T. Barry, Mary A McLean
| Nature Verified
Abstract Fumarate hydratase-deficient renal cell carcinoma (FHd-RCC) is a rare and aggressive renal cancer subtype characterised by increased fumarate accumulation and upregulated lactate production. Renal tumours demonstrate significant intratumoral metabolic heterogeneity, which may contribute to treatment failure. Emerging non-invasive metabolic imaging techniques have clinical potential to more accurately phenotype tumour metabolism and its heterogeneity.
Open in Who Shared Issue with article?

PARP inhibition generates enhanced CD8+ central memory T cells by transcriptional and metabolic reprogramming - Nature Immunology

|
By Pankaj Gaur, Nour Shobaki, Simon T. Barry, Vivek Verma, Seema Gupta Verified, Christopher Priestley-Milianta
| Nature Verified
Abstract CD8+ central memory T (TCM) cells provide stronger antitumor immunity than more-differentiated effector memory counterparts. Here we show that poly(ADP-ribose) polymerase (PARP) inhibition induces CD8+ TCM cells with superior memory by activating the SIRT-1–FOXO1 pathway and inducing metabolic and transcriptional switches through inhibition of enzymatic activity and enhanced PARP trapping.
Open in Who Shared Issue with article?
See all 43 licensed articles (45 Total)