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Roshan Xavier Norman

As seen in: BioRxiv, Cell Press
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Articles

ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

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By Yanyang Chen, Roshan Xavier Norman, Eléonore Toufektchan, Xiaohan Luan, Abraham Shim, Hannah Rosenberg, Márton Kovács, Ashley Nichols, James Hickling, Paolo Cifani, Alex Kentsis, Wen Zhou, John Maciejowski
| Cell Press Verified
Keywords TREX1 BAF cGAS STING micronuclei chromothripsis chromosomal instability Get full text access Log in, subscribe or purchase for full access. References 1. Cimini, D. Merotelic kinetochore orientation, aneuploidy, and cancer Biochim. Biophys. Acta. 2008; 1786:32-40 2. Guo, X. ∙ Ni, J. ∙ Liang, Z. ... The molecular origins and pathophysiological consequences of micronuclei: New insights into an age-old problem Mutat. Res. Rev. Mutat. Res. 2019; 779:1-35 3. Hatch, E.M. ∙ Fischer, A.H. ∙ Deerinck, T.J. ...
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Mitotic transcription ensures ecDNA inheritance through chromosomal tethering

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By Ashley Nichols, Yanyang Chen, Yujin Choi, Roshan Xavier Norman
| BioRxiv
Abstract Extrachromosomal DNA (ecDNA) are circular DNA bodies that play critical roles in tumor progression and treatment resistance by amplifying oncogenes across a wide range of cancer types. ecDNA lack centromeres and are thus not constrained by typical Mendelian segregation, enabling their unequal accumulation within daughter cells and associated increases in copy number.
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