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Rossella Barone

As seen in: ScienceDirect, MDPI
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Articles

A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for Measuring Fosfomycin Concentrations in Human Prostatic Tissue

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By Matteo Conti, Beatrice Giorgi, Rossella Barone, Milo Gatti
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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A validated LC-MS/MS method for the quantitation of daratumumab in rat serum using rapid tryptic digestion without IgG purification and reduction

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By Rossella Barone, Susi Pelotti, Kimon Runge, Zhongwu Guo
| ScienceDirect Verified
Introduction Daratumumab (DARA), developed by Janssen Pharmaceuticals and FDA-approved in 2015, is a humanized immunoglobulin G (IgG) 1k subclass monoclonal antibody (mAb) [1]. It is a key player in treating immunoglobulin light-chain amyloidosis, relapsed/refractory multiple myeloma (MM), and related conditions [2], [3], [4].
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Antibiotics | Free Full-Text | Fast and Sensitive Method for Simultaneous Quantification of Meropenem and Vaborbactam in Human Plasma Microsamples by Liquid Chromatography-Tandem Mass Spectrometry for Therapeutic Drug Monitoring

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By Rossella Barone, Matteo Conti, Milo Gatti, Beatrice Giorgi
| MDPI
1. Introduction Meropenem (MRP)-Vaborbactam (VBR) is the combination of a carbapenem with a first-in-class boronic acid-based β-lactamase inhibitor. VBR is added to the therapy to restore the antibacterial effect of MRP by blocking its degradation promoted by the serine beta-lactamases. This antibiotic protects a primary β-lactam, MRP, with a new β-lactamase inhibitor, and expands the limited options for the treatment of multidrug-resistant Gram-negative infections.
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