Ruanne V Barnabas
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Efficacy and durability of immediate versus delayed single-dose HPV vaccination for persistent infection among young women in Kenya: a randomized, blinded, cross-over clinical trial
Abstract Evidence is needed for single-dose human papillomavirus (HPV) vaccine efficacy (VE) durability to support vaccination guidelines. In this randomized crossover trial (NCT03675256), healthy young women aged 15-20 years, recruited through community-based screening in Kenya, were randomly allocated to immediate nonavalent or bivalent HPV vaccination and delayed control at month 30/36 (age 17-23 years), or immediate control and delayed nonavalent HPV vaccination.
Evidence to Action — Single-Dose HPV Vaccination and Cervical HPV Infection | NEJM
Are you a member of an institution such as a university or hospital?Learn more about Institutional Access Notes This editorial was published on December 3, 2025, at NEJM.org. Disclosure forms provided by the author are available with the full text of this editorial at NEJM.org. Supplementary Material Disclosure Forms (nejme2515387_disclosures.pdf)
Leveraging behavioral economics strategies to close gaps in biomedical HIV prevention
Globally, HIV incidence is falling due to tremendous advances in HIV treatment and prevention. However, gaps exist, with 1.3 million new infections globally in 2023 and the world remaining well behind on pre-exposure prophylaxis (PrEP) goals [1]. In 2023, the HIV incidence rate among adolescent girls and young women (AGYW) in southern Africa was over 3 times that of their male counterparts [1], with the gender disparity in Cameroon being a factor of 5 [2].
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