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ABSTRACT Clopidogrel is a widely prescribed antiplatelet prodrug, with activation affected by CYP2C19 loss- and gain-of-function variants. Whilst global CYP2C19 variant prevalence is well described, this scoping review characterises CYP2C19 diplotype and metaboliser phenotype frequencies in clopidogrel-indicated populations. A literature search of Scopus, PubMed, Ovid MEDLINE, and Ovid Embase was conducted from inception to 6 July 2026.
Introduction Pharmacogenomics refers to the influence of genetic variation on drug pharmacokinetics and pharmacodynamics.1 By predicting an individual's likely drug response, pharmacogenomics can guide drug and dose selection and facilitate precision medicine.1 Pharmacogenomic-guided prescribing may improve treatment efficacy and reduce adverse drug events.2 In Australia, medication-related hospitalisations account for an estimated 250 000 admissions and approximately 1.4 billion Australian...
ABSTRACT Poor knowledge and confidence in pharmacogenomics are key barriers to implementation. Education of future healthcare professionals is required to enhance appropriate use of pharmacogenomics, however, the optimal education approach is unclear. This systematic scoping review evaluates pharmacogenomic educational interventions to improve knowledge and confidence. A total of 24 studies were included.
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