Rudolf Merkel on Muck Rack

Rudolf Merkel

As seen in: Nature, Cell Press
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Articles

Crumbs2 acts as a dynamic cellular sensor triggering stable podocyte cell-matrix anchorage.

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By Rohan Bhatia, Annika Möller-Kerutt, Sven Gerlach, Rebecca Rixen, Hermann Pavenstädt, Bernd Hoffmann, Rudolf Merkel, Ulrich Kubitscheck, Thomas Weide, Yannick Herfs, Jan Peter Siebrasse
| Cell Press Verified
ArticleOnline nowOpen access 1Clausius Institute of Physical and Theoretical Chemistry, Wegelerstr.
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Polarity signaling balances epithelial contractility and mechanical resistance - Scientific Reports

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By Matthias Rübsam, Rudolf Merkel
| Nature Verified
Abstract Epithelia maintain a functional barrier during tissue turnover while facing varying mechanical stress. This maintenance requires both dynamic cell rearrangements driven by actomyosin-linked intercellular adherens junctions and ability to adapt to and resist extrinsic mechanical forces enabled by keratin filament-linked desmosomes. How these two systems crosstalk to coordinate cellular movement and mechanical resilience is not known.
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Regulation of keratin network dynamics by the mechanical properties of the environment in migrating cells

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By Rudolf Merkel, Rudolf E. Leube, Sungjun Yoon, Reinhard Windoffer
| Nature Verified
Abstract Keratin intermediate filaments provide mechanical resilience for epithelia. They are nevertheless highly dynamic and turn over continuously, even in sessile keratinocytes. The aim of this study was to characterize and understand how the dynamic behavior of the keratin cytoskeleton is integrated in migrating cells.
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