Ruensern Tan on Muck Rack

Ruensern Tan

As seen in: Nature, Cell Press, eLife, Annual Reviews Journal
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Articles

A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

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By David Trombley McSwiggen, Helen Liu, Ruensern Tan, Sebastià Puig
| eLife
eLife assessment This work presents an important technological advance, in the form of a high throughput platform for Single Particle Tracking allowing us to measure millions of cells and thousands of compounds per day. Analysis of the diffusional behaviour of fluorescently-tagged targets permits the identification of, and differentiation between, small molecules that bind directly or affect the target indirectly.
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A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

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By David T. McSwiggen, Helen Liu, Ruensern Tan, Sebastià Puig
| biorxiv.org
Abstract The regulation of cell physiology depends largely upon interactions of functionally distinct proteins and cellular components. These interactions may be transient or long-lived, but often affect protein motion.
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High-throughput single molecule tracking identifies drug interactions and cellular mechanisms

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By David T. McSwiggen, Helen Liu, Ruensern Tan, Sebastià Puig
| biorxiv.org
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