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Abstract Small-molecule PI3Kγ inhibitors can reprogram immunosuppressive myeloid cells but are limited by rapid clearance, lack of cell-type selectivity, and systemic exposure to non-target tissues. Here, we extended a previously developed folate receptor (FR)-directed 6-substituted pyrrolo[2,3-d]pyrimidine ligand to the intracellular delivery of AS-252424.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
