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Ruijuan Yin on Muck Rack

Ruijuan Yin

As seen in: MDPI, ACS Publications, Science Magazine
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Articles

Discovery of Potent and Selective Imidazo[2,1-b][1,3,4]thiadiazole-Based MNK1/2 Inhibitors with Significant Efficacy against Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease

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By Tingting Qiu, Xin Jin, Ruijuan Yin
| ACS Publications
Abstract Click to copy section linkSection link copied! Mitogen-activated protein kinase-interacting kinases (MNK1/2) have emerged as promising therapeutic targets for metabolic dysfunction-associated steatotic liver disease (MASLD).
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Achieving cysteine-selective peptide/protein bioconjugation via tunable triazine-pyridine chemistry

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By Doeke R. Hekstra, David Ottenheimer, Ivana Maric, Chaoming Wang, Ruijuan Yin, Hao Jiang, Hongli Zhang, Rilei Yu, Han Liu, Xuechen Li, Tao Jiang, Qinbo Ma, Shanyue Zheng
| Science Magazine Verified
Abstract The development of cysteine (Cys)–selective bioconjugation reagents with enhanced stability remains a critical challenge for therapeutic applications such as antibody-drug conjugates (ADCs). Leveraging the modular 1,3,5-triazine scaffold, we report the design and optimization of triazine-pyridinium chemistry (TPC) reagents for selective Cys labeling.
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Novel Camptothecin Derivative 9c with Enhanced Antitumor Activity via NSA2-EGFR-P53 Signaling Pathway

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By Fu Du, Aotong Zhang, Xin Qi, Ruijuan Yin
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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