Runqiu Song

Submitted: 28 February 2025 You are already at the latest version Antigen presentation on major histocompatibility complex (MHC) molecules is central to the initiation of immune responses and a lot of our understanding about the antigen processing and presentation pathway has been gained through studies in mice. MHC molecules are the most genetically diverse genes, consequently mouse strains differ substantially in their MHC make up and resulting antigen presentation.

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Abstract Abstract: The generation of bone marrow-derived dendritic cells is a widely used approach in immunological research to study antigen processing and presentation as well as T cell activation responses. However, the initial step of isolating the bone marrow can be time-consuming, especially when larger numbers of precursor cells are required.