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Ruoqing Feng

As seen in: Cell Press
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Articles

Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions

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By Ruoqing Feng, Lena Spieth, Lu Liu, Stefan A. Berghoff, Jonas Franz, Qian Liu, Zhen Wang, Vini Tiwari, Simona Vitale, Simon Frerich, Sergi Florensa, Niklas O. Junker, Ludwig Huber, Marco Keller, Christoph Müller, Franz Bracher, Xiaoke Ge, Patrick C.N. Rensen, Leon Hosang, Serhii Chornyi, Martin Dichgans, Ozgun Gokce, Gesine Saher, Christine Stadelmann, Martin Giera, Janos Groh, Mikael Simons, Gijs Kooij
| Cell Press Verified
Keywords multiple sclerosis neuroinflammation glia microglia CD8+ T cells CD8+ tissue-resident memory T cells myelin spatial transcriptomics lipids Introduction Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) characterized by demyelination and neurodegeneration, typically progressing from a relapsing-remitting phase to a chronic progressive course.1,2 Relapses result from the migration of activated peripheral immune cells into the CNS, where they...
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