Ruthe Foushee

1 Introduction If you have ever read a young child a bedtime story, you have likely noticed how children will demand that you read some books over and over again, yet insist that you abandon others just as you begin. Moreover, the same—relatively simple—book that a toddler demands over and over may bore a preschooler, whose favorite—comparatively complex—book the toddler immediately rejects.

Actin polymerization counteracts prewetting of N-WASP on supported lipid bilayers Edited by David Weitz, Harvard University, Cambridge, MA; received April 15, 2024; accepted October 27, 2024 Significance Liquid–liquid phase separation has emerged as a key mechanism for intracellular compartmentalization. How proteins condense in cells under nonequilibrium conditions remains a fundamental question.

Significance Oral squamous cell carcinoma is genetically heterogeneous and has a poor 5-y survival rate. To explore the role of inactivating mutations in Caspase-8, we deleted the gene in the oral cavity of mice. This resulted in an epithelial barrier defect and neutrophil infiltrate, both of which were linked to the induction of autophagy in epithelial cells. On treatment with a chemical carcinogen deletion of Caspase-8 resulted in increased reactive oxygen species and tumor susceptibility.