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Rutwik Bardapurkar on Muck Rack

Rutwik Bardapurkar

As seen in: Wiley Online Library, BioRxiv, Cell Press
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Articles

Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat stress

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By Hanna Achache, Hanna Schon, Leonid Kontorovich, Guy Teichman, Shir Weiss, Anna Mogilevskaya, Myriam Valenski, Sarit Anava, Rutwik Bardapurkar, Hila Gingold, Rachel Posner, Olga Antonova, Mario De Bono, Yonatan B Tzur, Oded Rechavi
| Cell Press Verified
Introduction Reproductive health is strongly influenced by environmental factors. Mass extinctions are happening on an unprecedented scale, driven, in large part, by rising global temperatures that cause widespread fertility loss. Climate change is linked to declining male and female fertility from plants to mammals, posing a significant challenge for future generations.1,2 How do organisms endure and adapt in such difficult times?
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Trophic microRNA: Post‐transcriptional regulation of target genes and larval development impairment in Plutella xylostella upon precursor and mature microRNA ingestion

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By Rutwik Bardapurkar, Agricultural Biotechnology, Research Pune India, Gauri Binayak
| Wiley Online Library Verified
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description imb12949-sup-0001-Supinfo.pdfPDF document, 1.3 MB Figure S1. Endogenous pre-let-7 and let-7 levels. Figure S2. Secondary structures of pre-let-7 and pre-C. Figure S3. miRNA stability in AD. Figure S4. let-7 target binding site as predicted by RNAhybrid. Figure S5. miRNA concentration optimization for the trophic delivery in the first instar P. xylostella larvae. Figure S6.
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Trophic microRNA: Precursor and mature microRNA ingestion downregulates the target transcripts and hampers larval development in Plutella xylostella

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By Sagar Pandit, Rutwik Bardapurkar
| BioRxiv
Abstract MicroRNAs (miRNAs) are post-transcriptional gene regulators. In the miRNA pathway's cytoplasmic part, the miRNA is processed from a hairpin-structured precursor (pre-miRNA) to a double-stranded (ds) mature RNA and ultimately to a single-stranded mature miRNA. In insects, ingesting these two ds forms can regulate the target gene expression; this inspired the trophic miRNA's use as a functional genomics and pest management tool.
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