Ryan Sheehy on Muck Rack

Ryan Sheehy

Dover, Florida
As seen in: Townsquare Media, WCYY-FM (Portland, ME), Nature, Cell Press, DataCamp, Vanderbilt Hustler, JMU Breeze
Born and raised in New Hampshire! Brrrrrr!

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Articles

Segregated supramammillary-dentate gyrus circuits modulate cognitive and affective function in healthy and Alzheimer’s disease model mice

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By Yan-Jia Luo, Longfei Li, Ze-Ka Chen, Ping Dong, Ling Xie, W. Todd Farmer, Qing-Song Yu, Wei-Kun Su, Hong-Shan Liu, Zhuo-Lei Jiao, David Melville, Ryan Sheehy, Taylor Landry, Jing Wang, Hong Jiang, Xiao-Hong Xu, Xian Chen, Nan-Jie Xu, Tian Xue, Tian-Le Xu, Ya-Dong Li, Juan Song, Lian-Xiang Jiang, Hua-Zhi Wang, Emma Penel
| Cell Press
Keywords Alzheimer’s disease emotion memory hypothalamus supramammillary-dentate gyrus circuits Get full text access Log in, subscribe or purchase for full access. References 1. Selkoe, D.J. Alzheimer's disease: genes, proteins, and therapy Physiol. Rev. 2001; 81:741-766 2. Selkoe, D.J. Alzheimer's disease is a synaptic failure Science. 2002; 298:789-791 3. Ehrenberg, A.J. ∙ Suemoto, C.K. ∙ França Resende, E.P. ... Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease J. Alzheimers.
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Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity

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By Taylor Landry, Laura Perrault, David Melville, Zhe Chen, Ya-Dong Li, Ping Dong, W. Todd Farmer, Brent Asrican, Hannah Lee , Libo Zhang, Ryan Sheehy, Corina Damian, Thomas J. Collins, Nehemiah Stewart, E.S. Anton, Juan Song
| Cell Press
Keywords hippocampus dentate gyrus CCK interneurons hyperactivity PKM2 phosphorylation of PKM2 cognitive decline metabolic disorders glucose obesity high-fat diet learning and memory Get full text access Log in, subscribe or purchase for full access. References 1. Winocur, G. ∙ Greenwood, C.E. Studies of the effects of high fat diets on cognitive function in a rat model Neurobiol. Aging. 2005; 26:46-49 2. Van Gelder, B.M. ∙ Tijhuis, M. ∙ Kalmijn, S. ...
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Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology - Nature Communications

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By Ryan Sheehy, Adil Muneer, Yan Xiong, John A. Wrobel, Feng Zhang, Kwang-Su Park, Jing J. Liu, Brent Asrican, Ping Dong, Ya-Dong Li, Yongyi Li, Guo-li Ming, Hongjun Song, Zhexing Wen, Jian Jin, Juan Song, Mohanish Deshmukh
| Nature
Abstract Current Aβ-targeting therapeutics for Alzheimer’s disease (AD) only slow cognitive decline due to poor understanding of AD pathogenesis. Here we describe a mechanism of AD pathogenesis in which the histone methyltransferase G9a noncanonically regulates translation of hippocampal proteins associated with AD pathology.
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