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Articles by Saeed Ullah
General Relativity and Quantum Cosmology
In this manuscript, we study circular geodesics and twin-peak high-frequency quasi-periodic oscillations (HF-QPOs) in the charged Simpson--Visser--anti-de Sitter (AdS) spacetime, which depends on a charge parameter $Q$, a regularization scale $b$ and an AdS radius $l$.
Facile one-pot multicomponent synthesis of polyhydroquinolines: a new class of α-glucosidase inhibitors
Abstract A series of 20 novel polyhydroquinolines (1–20) were synthesized via a simple, efficient and straightforward way of four-component reaction using a one-pot synthetic method in good-to-excellent/high yields. All synthesized compounds were characterized using spectroscopic techniques such ¹H NMR, ¹³C NMR, and High-Resolution Mass Spectrometry (HRMS-ESI+) to confirm their structures.
General Relativity and Quantum Cosmology
In this article, we examine particle dynamics and Quasi-periodic oscillations within a charged Simpson-Visser-Anti-de Sitter (AdS) spacetime. We first analyze the behavior of the metric and black hole horizons under the competing impact of electric charge $Q$, regularization parameter $b$, and AdS radius $l$.
General Relativity and Quantum Cosmology
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Bioassay-guided isolation of a new cytotoxic compound targeting carbonic anhydrase-II: in-vitro structure-activity relationships and dynamics studies
Abstract Bioassay-guided isolation of Anogeissus dhofarica A.J. Scott afforded one new natural product (lupeol butyl ether, 1), along with sixteen known metabolites (2–17) reported from this source for the first time. Structural elucidation of the isolates was performed by NMR and mass spectrometry. An in vitro carbonic anhydrase-II (CA-II) inhibition assay was performed on the crude extract, the fractions, and the resulting pure constituents.
Simulation of Full Wavefield Data with Deep Learning Approach for Delamination Identification
1. Introduction Detecting delamination in composite materials poses a significant challenge for conventional visual inspection techniques, as it occurs between the plies of the composite laminate and remains invisible from external surfaces [1,2]. As a result, various nondestructive testing (NDT) and structural health monitoring (SHM) techniques have been proposed for delamination identification in composite structures.
Carbonylbis(hydrazine‐1‐carbothioamide) derivatives as a new class of α‐glucosidase inhibitors and their mechanistic insights via molecular docking and dynamic simulations
CONFLICTS OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description ardp202300604-sup-0001-InChI_Code_and_Biological_Activity.docx19.2 KB Supporting information. ardp202300604-sup-0002-Supporting_Information.docx10.2 MB Supporting information. REFERENCES 1, , , , , , , , , , , , , , Molecules 2022, 27, 6921. https://doi.org/10.3390/molecules27206921 2, , , , Eur. J. Med. Chem. 2023, 249, 115119.
Synthesis of 3‐hydroxy‐2‐naphthohydrazide‐based hydrazones and their implications in diabetic management via in vitro and in silico approaches
CONFLICTS OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description ardp202300544-sup-0001-InChI_Codes_and_Biological_Activity.docx19.5 KB Supporting information. ardp202300544-sup-0002-Supporting_Information_R1.docx8.5 MB Supporting information. REFERENCES 1, , , , , , , , Eur. J. Med. Chem. 2015, 93, 443. 2, , , , Pharmacogn. Rev. 2011, 5(9), 19. 3, , , , , , Curr. Vasc. Pharmacol. 2020, 18(2), 104. 4, , , J. Diabetes Metab. Disord. 2013, 12(1), 1.
Synthesis, density functional theory and kinetic studies of aminopyridine based α-glucosidase inhibitors
**Author for correspondence: E-mail Address: hej@cyber.net.pk https://orcid.org/0000-0001-5356-3585 H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan Department of Biochemistry, King Abdul Aziz University, Jeddah, 21452, Saudi...
Charged particle dynamics in black hole split monopole magnetosphere
The European Physical Journal C, Aug 2023 This article examines particle dynamics and acceleration in the magnetic Penrose process (MPP) around Kerr black hole (BH) in a split monopole magnetic field.
Effectiveness of Betamethasone Soaked Throat Pack Compared to Saline Soaked Throat Pack in Reducing Post-Operative Throat Pack-Associated Sore Throat
Abstract Objective: To compare the effectiveness of Betamethasone topical solution against Normal Saline in reducing post-operative sore throat after pharyngeal/packing in ENT surgeries. Study Design: Quasi-experimental study. Place and Duration of Study: Combined Military Hospital Sialkot Pakistan, from Apr to Dec 2019. Methodology: The study was conducted on 238 patients undergoing ENT surgery requiring throat pack placement. Patients were randomly divided into two groups.
Discovery of new boswellic acid hybrid 1H-1,2,3-triazoles for diabetic management : in vitro and in silico studies
Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/101961 Title: Discovery of new boswellic acid hybrid 1H-1,2,3-triazoles for diabetic management : in vitro and in silico studies Type: Article Language: English Abstract: A series of 24 new 1H-1,2,3-triazole hybrids of 3-O-acetyl-11-keto-β-boswellic acid (β-AKBA (1)) and 11-keto-β-boswellic acid (β-KBA (2)) was designed and synthesized by employing “click” chemistry in a highly efficient manner.
GC-MS Profiling and Biomedical Applications of Essential Oil of Euphorbia larica Boiss.: A New Report
1. Introduction Medicinal plants are the prime source of alternative therapy for diabetes mellitus (DM) and numerous other human health complications [1]. Essential oils (EOs) produced from plants have multiple pharmacological and pharmaceutical properties including microbial resistance [1,2,3], scavenging free radicals [2,3], curing inflammation [4,5,6], α-glucosidase inhibition [7], carbonic anhydrase-II inhibition [8,9], and relieving pain [10].
A Comparative Analysis of Body Image, Life Satisfaction and Self-Esteem of Patients Before and After Rhinoplasty
Abstract Objective: To answer whether life satisfaction, self-esteem and body image rate differ significantly in patients before and after aesthetic rhinoplasty. Study Design: Quasi-experimental study. Place and Duration of Study: Combined Military Hospital, Sialkot and Combined Military Hospital, Rawalpindi Pakistan,from Aug 2019 to Aug 2021. The study was conducted on 60 male and female participants between the age of 20-50 years.
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