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Saiying Wang

As seen in: Nature, Dove Medical Press, European Journal of Obstetrics & Gynaecology and Reproductive Biology
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Articles

First-in-Human Phase I Trial of HRS-2129, a Selective Nav1.8 Inhibitor: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects

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By Jie Huang, Qian Wu, Saiying Wang
| Dove Medical Press
Jie Huang,1– 4 Qian Wu,2,3 Saiying Wang,5 Jinlian Xie,2,3 Kunhong Deng,2,3 Shuang Yang,2,3 Xiaoyan Yang,2,3 Chuanpin Chen,1 Guoping Yang1– 4 1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, People’s Republic of China; 2Research Center of Drug Clinical Evaluation, Central South University, Changsha, Hunan, People’s Republic of China; 3Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Huan, People’s Republic of...
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NH600001, an etomidate analogue, provides gastrointestinal endoscopy sedation/anesthesia and reduces adrenocortical depression: two randomized controlled trials

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By Yingyong Zhou, Kaiming Duan, Shichao Luo, Shengping Liu, Songhua Liu, Huajing Guo, Haitao Jiang, Guyan Wang, Huijun Wang, Zhiping Wang, Xiaobao Zhang, Canlin Sun, Qiang Wang, Wei Gao, Zhongyuan Xia, Ailin Luo, Chun C Chen, Mengchang Yang, Wenjie Su, Xiaohua Zou, Yalan Li, Hao Wang, Yanjuan Huang, Ruping Dai, Qian Zhao, Linzhong Zhang, Wenjun Yan, Xingang Qin, Juan Wang, Jingli Chen, Jun Cao, Wen Ouyang, Saiying Wang, Qiongcan Li, Wangning Shangguan, Shuan Jing, Minsheng Zhang, Shuchun Yu
| Nature Verified
Abstract To evaluate the efficacy and safety of NH600001, a novel etomidate derivative, in gastrointestinal endoscopy, as well as its impact on adrenocortical function, two multicenter, double-blind, randomized, controlled clinical trials(NH600001-21 [Phase II trial] and NH600001-31 [Phase III trial]) were conducted in China. In NH600001-21, 160 gastroscopy subjects were randomized 1:1:1:1 to receive NH600001 (0.20, 0.25, or 0.30 mg/kg) and etomidate (0.30 mg/kg).
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Generic Intravenous Amisulpride (QLG2069) for the Prevention of Postop

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By Hong Hai Zhang, Saiying Wang, Mengchang Yang, Yanjuan Huang
| Dove Medical Press
Back to Journals » Drug Design, Development and Therapy » Volume 19 Authors Zhang H , Wang S, Yang M, Huang Y , Wang K, Jiang K , Luo F, Hu X , Hong Y, Huang F, Jin S , Qi F, Wang S, Zhang X, Luo H, Guo L, Zhang L , Li J, Chen Y, Qin Z, Chen C, Yang J , Jiang W, Fu N, Ju Y, Li Y , Wang J, Ouyang W, Feng Y Received 15 April 2025 Accepted for publication 15 August 2025 Published 3 September 2025 Volume 2025:19 Pages 7707—7718 DOI https://doi.org/10.2147/DDDT.S529526 Checked for plagiarism Yes...
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