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Salil Saurav Pathak on Muck Rack

Salil Saurav Pathak

As seen in: BioRxiv, Cell Press
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Articles

Limited Expression of Nrf2 in Neurons Across the Central Nervous System

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By Salil Saurav Pathak, Matthew R. Slattery, Daniel C Levings, Yi-Mei Yang
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.05.09.540014 Abstract Nrf2 is a broadly expressed transcription factor that regulates gene expression in response to reactive oxygen species (ROS) and oxidative stress. It is commonly referred to as a ubiquitous pathway, but this generalization overlooks work indicating that Nrf2 is essentially unexpressed in some neuronal populations.
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The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

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By Dong Liu, Tianbao Li, Salil Saurav Pathak
| Cell Press Verified
Highlights • GCN2 rhythmically phosphorylates eIF2α in the suprachiasmatic circadian clock • eIF2α phosphorylation bidirectionally controls circadian period in cells and mice • eIF2α phosphorylation promotes mRNA translation of Atf4 • ATF4 binds to the Per2 promoter region and activates its transcription Summary The integrated stress response (ISR) is activated in response to diverse stress stimuli to maintain homeostasis in neurons.
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