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Articles by Sameet Mehta
Central nervous system B cell multiomics reveals a legacy of immune dysregulation in long-term treated HIV infection
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Despite effective antiretroviral therapy (ART), people with HIV (PWH) are at risk for central nervous system (CNS) abnormalities, including cognitive impairment.
Central nervous system B cell multiomics reveals a legacy of immune dysregulation in long-term treated HIV infection
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Despite effective antiretroviral therapy (ART), people with HIV (PWH) are at risk for central nervous system (CNS) abnormalities, including cognitive impairment.
"Early Cellular and Molecular Signatures Correlate With Severity of Wes" by Ho-Joon Lee, Yujiao Zhao et al.
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Early cellular and molecular signatures correlate with severity of West Nile virus infection
Infection with West Nile virus (WNV) drives a wide range of responses, from asymptomatic to flu-like symptoms/fever or severe cases of encephalitis and death. To identify cellular and molecular signatures distinguishing WNV severity, we employed systems profiling of peripheral blood from asymptomatic and severely ill individuals infected with WNV.
Early Deprivation Impairs Perforant Pathway Connectivity and Contextual Memory in Adolescent Male Mice
Abstract Early-life adversity causes reduced hippocampal volume and abnormal hippocampal connectivity and function, with evidence indicating more prominent deficits in males compared to females. Reelin-positive projections from the lateral entorhinal cortex (LEC) to the dorsal hippocampus are essential for encoding contextual and semantic memories in diverse mammalian species, including humans and rodents.
Early cellular and molecular signatures correlate with severity of West Nile Virus infection
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Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas - Nature Communications
Abstract Although mitochondrial activity is critical for angiogenesis, its mechanism is not entirely clear. Here we show that mice with endothelial deficiency of any one of the three nuclear genes encoding for mitochondrial proteins, transcriptional factor (TFAM), respiratory complex IV component (COX10), or redox protein thioredoxin 2 (TRX2), exhibit retarded retinal vessel growth and arteriovenous malformations (AVM).
Council Post: Three Ways Startups Can Stay On Track Amid Uncertainty
Sameet Mehta is Managing General Partner at Granite Hill Capital Partners. There has been a lot of uncertainty for tech. Over the past year, we’ve seen the valuations of public tech companies plummet, with some companies off as much as 80% to 90% from their all-time highs. In many cases, those highs were only reached about a year ago.
Council Post: The Three Traits Of Highly Effective VCs
Sameet Mehta is Managing General Partner at Granite Hill Capital Partners. Venture capital (VC) investing, done well, requires the right amount of capital and the right amount of industry expertise invested in a startup at the right time. At its best, venture capital delivers a clear advantage to a startup that propels it through its critical growth stages and continues to add value throughout the company’s lifecycle.
Ways It Will Be Different in 2022
You are here: Home / Industry News / VC Is Charging Ahead and Changing Fast: Here Are 3 Ways It Will Be Different in 2022 Venture capital as an asset class has far outperformed other alternative-asset classes, including private equity, hedge funds and real estate, over the past several years. And it is not slowing down.
5 Guidelines for Founders When Choosing a VC Partner
We all know that VCs look for strong founders who are capable of leading their companies to extraordinary success. But what should founders look for when choosing a VC? Assuming you have the luxury of choice, here’s some things I suggest based on several years of working closely with founders and observing what’s worked and what hasn’t. In many cases, your investor(s) can have a significant influence on the path a company takes.
The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors
Joy E.
The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors
Joy E.
The Future of Free Speech
In the past several years technology has made speech dramatically more powerful and free than was conceivable in the past. In 2017, with a highly charged atmosphere locally and globally, the question of how the concept of freedom of speech is going to modernize is coming to the fore. A key issue is how far big internet platforms like Facebook and YouTube will go to clamp down on extremist speech.
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