Sammy Weiser Novak on Muck Rack

Sammy Weiser Novak

As seen in: Science Magazine, BioRxiv, Cell Reports
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Articles

In situ proteomics unveils specialized domains for extrasynaptic signaling on neuronal cilia

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By Yentli E. Soto Albrecht, Oded Liran, Roddy M. Grieves, Chia-Hsiang Chang, Van Ngu Trinh, Sammy Weiser Novak, Nidhi Rani Lokesh, Catalina Kretschmar Montecinos, Daniela Boassa, Mark Pownall Verified, Marian Kalocsay, Maxence V. Nachury
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Neuronal cilia have emerged as crucial signaling hubs, yet their molecular composition and integration with synaptic communication remain poorly understood.
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Astrocyte glypican 5 regulates synapse maturation and stabilization

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By Alexandra P Bosworth, Minerva Contreras, Laura Sancho, Isabel Salas, Adrien Paumier, Sammy Weiser Novak, Uri Manor, Nicola J. Allen
| Cell Reports Verified
Keywords astrocyte synapse plasticity development neurodegeneration Research topic(s) CP: Neuroscience Introduction The formation and maturation of neuronal synapses during development is essential for circuit function throughout the lifespan. The transformation from immature nascent synapses to stable mature synapses in the adult involves structural changes at the pre- and postsynaptic terminals as well as shifts in neurotransmitter receptor composition.
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Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2

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By Haley Alleson Vecchiarelli, Kanchan Bisht, Kaushik P. Sharma, Sammy Weiser Novak
| BioRxiv
Abstract This study examined dark microglia-a state linked to central nervous system pathology and neurodegeneration-during postnatal development in the mouse ventral hippocampus, finding that dark microglia interact with blood vessels and synapses and perform trogocytosis of pre-synaptic axon terminals.
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