Samo Curk

Abstract Formation of new amyloid fibrils and oligomers from monomeric protein on the surfaces of existing fibrils is an important driver of many disorders such as Alzheimer’s and Parkinson’s diseases. The structural basis of this secondary nucleation process, however, is poorly understood. Here, we ask whether secondary nucleation sites are found predominantly at rare growth defects: irregularities in the fibril core structure incorporated during their original assembly.

Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma Lourdes Sainero-Alcolado https://orcid.org/0000-0002-9406-6478, Elisa Garde-Lapido https://orcid.org/0009-0001-5321-1253, Marteinn Thor Snaebjörnsson, +7 , Sarah Schoch, Irene Stevens https://orcid.org/0000-0003-3823-1499, María Victoria Ruiz-Pérez, Christine Dyrager https://orcid.org/0000-0003-4647-9769, Vicent Pelechano, Håkan Axelson https://orcid.org/0000-0002-7749-5043, Almut...

Given the way that Mark S. George describes the early days of his experiments with transcranial magnetic stimulation (TMS), potential patients might be wary. A professor of psychiatry at the Medical University of South Carolina and a pioneer of TMS, George recounts, for example, how the electrical circuits delivering current to coils would explode “with a blue flame” not all that far from the subject and the scientist.