Samudrala Gourinath

Conflict of interest The authors declare no conflict of interest. Supporting Information Filename Description febs17284-sup-0001-Supinfo.zipZip archive, 2.2 MB Fig. S1. Sequence homology analysis of KnPhot with phototropin (Phot) from different algae and higher plants. Fig. S2. Sequence homology analysis of KnPhot LOV1-LOV2 linker region with Phot(s) from different algae and higher plants. Fig. S3.

Abstract Entamoeba histolytica, an anaerobic parasite protozoan, is the causative agent of amoebiasis, the bloody diarrhea, and liver abscesses in humans. Amoebiasis is more predominant in tropical areas with poor sanitation conditions, and it remains the fourth leading cause of death due to a protozoan infection. E. histolytica life cycle spans between an infective 'cyst stage' and an active disease-causing 'trophozoite stage'. We have determined cryo- EM structures of E.

ABSTRACT Polyamines are essential for cell growth and proliferation. In plants and many bacteria, including Helicobacter pylori, the parent polyamine putrescine is only produced through the metabolism of N-carbamoylputrescine by N-carbamoylputrescine amidase (CPA). Thus, CPA is a crucial intermediate enzyme. Moreover, the absence of CPA in humans makes its presence in H. pylori a potential target for the development of new therapeutics against this pathogen.