Samuel Klein on Muck Rack

Samuel Klein

Missouri
As seen in: Nature, JAMA (The Journal of the American Medical Association), JAMA: Journal of the American Medical Association, Medscape, The New England Journal of Medicine, Cell Metabolism, Endocrine Today, Healio, JNeurosci, Diabetes Magazine and
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Articles

Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts

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By Snigdha Tiash, Saket Patel, Marjori Russo, Anusha Suresh, Yun-Ling Pai, Wentong Jia, Rachael Field, Terri Pietka, Nada A Abumrad, Gordon Smith , Dmitri Samovski, Samuel Klein, Jonathan R. Brestoff, Clair Crewe
| Cell Metabolism
Keywords extracellular vesicles exosomes spectral flow cytometry adipocyte macrophage mitochondria inter-organ signaling insulin resistance type 2 diabetes obesity Get full text access Log in, subscribe or purchase for full access. References 1. Xiao, J. ∙ Sluijter, J.P.G. Extracellular vesicles in cardiovascular homeostasis and disease: potential role in diagnosis and therapy Nat. Rev. Cardiol. 2025; 22:883-895 2. Isaac, R. ∙ Reis, F.C.G. ∙ Ying, W. ...
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N-acetylaspartate from fat cells regulates postprandial body temperature - Nature Metabolism

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By Jessica Felix, Holly Quang, Layla A Abushamat, Christie M. Ballantyne, Christopher I. Amos, Philip L. Lorenzi, Samuel Klein, Xia Gao
| Nature
Abstract N-acetylaspartate (NAA), the brain’s second most abundant metabolite, provides essential substrates for myelination through its hydrolysis1. However, the physiological roles of NAA in other tissues remain unknown. Here, we show that aspartoacylase (ASPA) expression in white adipose tissue (WAT) governs blood NAA levels for postprandial body temperature regulation.
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Plasma endotrophin levels correlate with insulin resistance in people with obesity

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By Gordon Smith, Samuel Klein
| The Journal of Clinical Investigation
Research LetterClinical ResearchMetabolismMuscle biology Open Access | 10.1172/JCI190577 J Clin Invest. https://doi.org/10.1172/JCI190577. Copyright © 2025, Smith et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract BACKGROUND.
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