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Sámuel Komoly on Muck Rack

Sámuel Komoly

As seen in: Seizure - European Journal of Epilepsy
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Articles

Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness

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By Máté Gyimesi, Adam Horvath, Demeter Túrós, Sharad Kumar Suthar, Louise Canon, Kathleen M. Ruppel, Darshan V. Trivedi, James A. Spudich, Mihály Kovács, Sámuel Komoly, Csilla Kurdi, Carlos Kikuti, Anna Á. Rauscher, Endre Pál
| ScienceDirect Verified
Highlights • A key residue variation of fast skeletal myosin allows selective targeting • A rationally designed inhibitor (MPH-220) specifically blocks skeletal muscle • The inhibitor-bound myosin atomic structure reveals mechanism of selectivity • MPH-220 improves gait disorders in spastic animal model after brain injury Summary Muscle spasticity after nervous system injuries and painful low back spasm affect more than 10% of global population.
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Ictal piloerection is associated with high-grade glioma and autoimmune encephalitis - results from a systematic review

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By Dalma Tényi, Beáta Bóné, Réka Horváth, Sámuel Komoly
| Seizure - European Journal of Epilepsy Verified
Publication History Published online: November 21, 2018Accepted: November 18, 2018; Received in revised form: November 15, 2018; Received: July 26, 2018;
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