Sandeep Ameta

Conflict of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description smll71491-sup-0001-SuppMat.pdf32.5 MB Supporting Information References 1, BioEssays 2010, 32, 296. 2, , Science 2013, 342, 1098. 3, , , , , , , , Nat. Commun. 2018, 9, 3643. 4, , , , , , Nat. Commun. 2019, 10, 490. 5, Rationalist Annual 1929, 148, 3.

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Abstract Robust localization of self-reproducing autocatalytic chemistries is a key step in the realization of heritable and evolvable chemical systems. While autocatalytic chemical reaction networks already possess attributes such as heritable self-reproduction and evolvability, localizing functional multispecies networks within complex primitive phases, such as coacervates, has remained unexplored.