Sandeep Datta

Keywords olfaction olfactory epithelium stem cells neurogenesis topographic map odor receptor olfactory receptor choice single-cell RNA sequencing MERFISH olfactory bulb axon guidance heterochromatin epigenetics Introduction The nervous system uses space to map sensation.1,2 The cochlea, for example, encodes different frequencies at distinct positions along its unrolled length; this tonotopic map is serially propagated through patterned projections to the brainstem, thalamus, and cortex.3...

eLife Assessment The authors present a biologically plausible framework for action selection and learning in the striatum that is a fundamental advance in our understanding of possible neural implementations of reinforcement learning in the basal ganglia.

Abstract Understanding the molecular logic of cortical cell-type diversity can illuminate cortical circuit function and evolution. Here, we performed single-nucleus transcriptome and chromatin accessibility analyses to compare neurons across three- to six-layered cortical areas of adult mice and across tetrapod species.