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sandeep joshi

United States
As seen in: PLOS, Scroll.in, Mechanical Engineering Magazine, The India Saga
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ShowFlipper offers a huge variety of fabric art, books as well as fine art paintings. Our exclusive collections also extend from jewelry designs to digital art. Shop from a range of creations directly uploaded by artists, authors, and designers. https://www.showflipper.com/

Articles

A direct link between MITF, innate immunity, and hair graying

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By Melissa Harris, Joseph Palmer, sandeep joshi, Temesgen D. Fufa
| PLOS
Melanocyte stem cells (McSCs) and mouse models of hair graying serve as useful systems to uncover mechanisms involved in stem cell self-renewal and the maintenance of regenerating tissues. Interested in assessing genetic variants that influence McSC maintenance, we found previously that heterozygosity for the melanogenesis associated transcription factor, Mitf, exacerbates McSC differentiation and hair graying in mice that are predisposed for this phenotype.
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17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model

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By sandeep joshi, Shunlin Jiang, Emmanual Unni, Stephen R. Goding
| PLOS
Heat shock protein 90 (HSP90) is a molecular chaperone which stabilizes client proteins with important roles in tumor growth. 17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of HSP90 ATPase activity, occupies the ATP binding site of HSP90 causing a conformational change which destabilizes client proteins and directs them towards proteosomal degradation.
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Upgrading Strategic Telecom Infrastructure: PM Narendra Modi Proposes, USOF Disposes

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By sandeep joshi
| The India Saga Verified
USOF is one organisation in the DoT’s scheme of things which has now become infamous for stalling government projects. Project after project it is creating hurdles which is leading to delay in projects of national importance.
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