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Sangni Qian on Muck Rack

Sangni Qian

As seen in: Taylor & Francis Online, Genome Medicine
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Articles

The ubiquitination of CD274 at MERCs enhances the anti-tumor immunity of cervical cancer

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By Xin Sun, Sangni Qian, Guiqin Ye
| Taylor & Francis Online
ABSTRACT Mitochondria-ER contact sites (MERCs) are crucial signaling hubs, but their role in anti-tumor immunity is unclear. This study revealed that the mitophagy regulator PRKN ubiquitinated CD274 at MERCs in human cervical cancer cells, a key mechanism for anti-tumor immunity. CD274 expression inversely correlated with PRKN in cervical cancer. Upon mitophagy activation, CD274 was recruited from ER to MERCs by PINK1, enhancing its interaction with PRKN.
Open in Who Shared Issue with article?

Developing an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies - Genome Medicine

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By Jianbo Tian, Ming Zhang, Fuwei Zhang, Kai Gao, Zequn Lu, Yimin Cai, Can Chen, Yanmin Li, Hao Bai, Yizhuo Liu, Heng Zhang, Xiangpan Li, Caibo Ning, Sangni Qian, Shuoni Chen
| Genome Medicine Verified
To develop a trans-ancestry PRS model for colorectal neoplasm, we used the Zhejiang colorectal cancer (ZJCRC) case–control set as the assessment set, ZJCRC cross-sectional screening set, and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cross-sectional screening set as the East Asian and European validation set respectively. We further tested in PLCO incident adenoma cohort and UK Biobank cohort (Additional file 1: Table S1-6).
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