Sanjana Shastri on Muck Rack

Sanjana Shastri

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Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing - Nature Neuroscience

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By Renhao Luo, Pius Schlachter, Mohamed Ariff Iqbal, Gabriele M Gassner, Sofia Mazuera, Sanjana Shastri, Sema Aygar, Logan Brase, Oscar Harari, Bruno A. Benitez
| Nature
Abstract Exercise’s protective effects in Alzheimer’s disease (AD) are well recognized, but cell-specific contributions to this phenomenon remain unclear. Here we used single-nucleus RNA sequencing (snRNA-seq) to dissect the response to exercise (free-wheel running) in the neurogenic stem-cell niche of the hippocampal dentate gyrus in male APP/PS1 transgenic AD model mice. Transcriptomic responses to exercise were distinct between wild-type and AD mice, and most prominent in immature neurons.
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