Mohamed Ariff Iqbal

Abstract Aerobic exercise is a disease-modifying intervention in multiple sclerosis (MS) that ameliorates several progressive neurological symptoms in people with MS. Here we show that the exercise hormone irisin mediates neuroprotective effects of exercise in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS.

Abstract Exercise’s protective effects in Alzheimer’s disease (AD) are well recognized, but cell-specific contributions to this phenomenon remain unclear. Here we used single-nucleus RNA sequencing (snRNA-seq) to dissect the response to exercise (free-wheel running) in the neurogenic stem-cell niche of the hippocampal dentate gyrus in male APP/PS1 transgenic AD model mice. Transcriptomic responses to exercise were distinct between wild-type and AD mice, and most prominent in immature neurons.

Ascl1 Achaete-scute homolog 1 ATF4 Activating transcription factor 4 ATP Adenosine triphosphate BF1 Brain factor-1 DAPI 4′,6-diamidino-2-phenylindole Dcx Doublecortin EdU 5-Ethynyl-2'-deoxyuridine ETC Electron transport chain GSH Glutathione GSSG Glutathione disulfide IHC Immunohistochemistry ISR Integrated stress response NAD Nicotinamide adenine dinucleotide NADH Reduced nicotinamide adenine dinucleotide NSC Neural stem cell OCR Oxygen consumption rate OPA1 Optic atrophy protein 1 OXPHOS...