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50,000 years of evolutionary history of India: Impact on health and disease variation

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By Elise Kerdoncuff, Laurits Rohden Skov, Nick Patterson, Joyita Banerjee, Pranali Y. Khobragade, Sankha Chakrabarti, Avinash Chakrawarty, Prasun Chatterjee, Minakshi Dhar, Monica Gupta, John John, Parvaiz A. Koul, Arokiasamy Perianayagam, Lalit Sankhe, Arunansu Talukdar, Mathew Varghese, Wei Zhao, Yuk Yee Leung, Gerard D. Schellenberg, Yi Wang, Jennifer Smith, Sharmistha Dey, Andrea Ganna, Aparajit Ballav Dey, Sharon Kardia, Jinkook Lee, Priya Moorjani, Sarabmeet S. Lehl, Rashmi R. Mohanty, Mekala Padmaja, Chhaya Rajguru, Sathyanarayana Raju Yadati
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Keywords genomic diversity in India South Asian evolutionary history ancient gene flow founder events Neanderthal ancestry Denisovan ancestry functional variation adaptation disease susceptibility peopling of India Introduction With more than 1.4 billion people and approximately 5,000 anthropologically well-defined ethno-linguistic and religious communities, India is a region of extraordinary diversity.1 Yet, Indian populations remain underrepresented in genomic studies.
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