Santhasiri Orrapin on Muck Rack

Santhasiri Orrapin

As seen in: Nature, MDPI
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Articles

Machine learning–based cfDNA fragmentation profiling using automated capillary electrophoresis for early detection of hepatocellular carcinoma - Communications Medicine

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By Sasimol Udomruk, Songphon Sutthitthasakul, Nuttida Bunsermvicha, Kanokwan Pinyopornpanish, Dumnoensun Pruksakorn, Phasit Charoenkwan, Petlada Yongpitakwattana, Kanlaya Khounkaew, Thanapak Jaimalai, Treephum Duangsan, Santhasiri Orrapin, Sutpirat Moonmuang, Pitiporn Noisagul, Arnat Pasena, Pathacha Suksakit, Ratikorn Gamngoen, Pimpisa Teeyakasem, Chaiyut Charoentum, Sarawut Kongkarnka, Worakitti Lapisatepun, Parunya Chaiyawat
| Nature
Abstract Early detection of hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited sensitivity of current surveillance tools, alpha-fetoprotein (AFP) and ultrasound. Recently, cell-free DNA (cfDNA) fragmentation analysis has shown promise in cancer detection; however, current sequencing-based approaches remain costly and unsuitable for large-scale screening.
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Deciphering the Biology of Circulating Tumor Cells through Single-Cell RNA Sequencing: Implications for Precision Medicine in Cancer

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By Santhasiri Orrapin, Patcharawadee Thongkumkoon, Sasimol Udomruk, Sutpirat Moonmuang
| MDPI
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IJMS | Free Full-Text | The Role of Proteomics and Phosphoproteomics in the Discovery of Therapeutic Targets and Biomarkers in Acquired EGFR-TKI-Resistant Non-Small Cell Lung Cancer

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By Apichat Tantraworasin, Sutpirat Moonmuang, Santhasiri Orrapin, Sasimol Udomruk
| MDPI
Abstract : The discovery of potent EGFR-tyrosine kinase inhibitors (EGFR-TKIs) has revolutionized the treatment of EGFR-mutated lung cancer. Despite the fact that EGFR-TKIs have yielded several significant benefits for lung cancer patients, the emergence of resistance to EGFR-TKIs has been a substantial impediment to improving treatment outcomes. Understanding the molecular mechanisms underlying resistance is crucial for the development of new treatments and biomarkers for disease progression.
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