Santhosh Kumar Subramanya on Muck Rack

Santhosh Kumar Subramanya

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A Novel Mouse Model of Parkinson's Disease for Investigating Progressive Pathology and Neuroprotection

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By Shreshth Shekhar, Sathyapriya Senthil, Santhosh Kumar Subramanya, Devu B Kumar
| biorxiv.org
Abstract Developing animal models that successfully recapitulate the features of progressive Parkinson′s disease (PD) is crucial for understanding disease progression mechanisms and creating effective therapeutic interventions. In this study, we created a mouse model of PD by overexpressing α-synuclein through a combined injection of AAV6-α-synuclein and preformed fibrils (PFFs) into the medial and lateral substantia nigra (SN).
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