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SARS-CoV-2 Entry Can Be Mimicked in C. elegans Expressing Human ACE2: A New Tool for Pharmacological Studies
Submitted: 17 September 2025 Posted: 18 September 2025 You are already at the latest version Testing medical countermeasures for SARS-CoV-2 transmission using vertebrates can be slowed by legislation regulating animal experimentation, high costs, and ethical concerns. To overcome these challenges, we propose a new Caenorhabditis elegans strain that constitutively expresses the human angiotensin-converting enzyme 2 receptor (ACE2).
A Comprehensive Technology Platform for the Rapid Discovery of Peptide Inhibitors against SARS-CoV-2 Pseudovirus Infection
Open AccessArticle by *,†, †, , , , , , and Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy * Author to whom correspondence should be addressed. † These authors contributed equally to this work. Int. J. Mol. Sci.
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