Sara Walli on Muck Rack

Sara Walli

As seen in: Nature, The Daily Mirror, Birmingham Mail, The Chronicle, Coventry Telegraph, Daily Post
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Articles

Inflammation reprograms fibro-adipogenic progenitors to sustain immunopathogenic niches in myositis

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By Christopher Nelke, Jin-Soo Park, Christina B. Schroeter, Felix Kleefeld, Anne-Katrin Güttsches, Sara Walli, Corinna Preusse, Alexander Mensch, Anne Schänzer, Markus Leo, Tim Hagenacker, Benedikt Schoser, Jörg H. W. Distler, Akiyoshi Uezumi, Werner Stenzel, Sven G. Meuth, Olivier Benveniste, Yves Allenbach, Tobias Ruck, Julian Sanchez-Dal Cin, Charles-Antoine Dallevet, Jacqueline C. Kinold, Paula Quint, Derya Cengiz, Vera Dobelmann
| Nature
Abstract Idiopathic inflammatory myopathies (IIMs) are autoimmune disorders defined by persistent muscle inflammation, fibrosis, and frequent resistance to current therapies. However, the mechanisms perpetuating disease activity despite immunosuppressive treatment remain elusive. Here, we describe a novel role for tissue-resident stromal cells, specifically fibro-adipogenic progenitors (FAPs), in sustaining skeletal muscle inflammation.
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