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Jörg H. W. Distler on Muck Rack

Jörg H. W. Distler

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Articles

Inflammation reprograms fibro-adipogenic progenitors to sustain immunopathogenic niches in myositis

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By Christopher Nelke, Jin-Soo Park, Christina B. Schroeter, Felix Kleefeld, Anne-Katrin Güttsches, Sara Walli, Corinna Preusse, Alexander Mensch, Anne Schänzer, Markus Leo, Tim Hagenacker, Benedikt Schoser, Jörg H. W. Distler, Akiyoshi Uezumi, Werner Stenzel, Sven G. Meuth, Olivier Benveniste, Yves Allenbach, Tobias Ruck, Julian Sanchez-Dal Cin, Charles-Antoine Dallevet, Jacqueline C. Kinold, Paula Quint, Derya Cengiz, Vera Dobelmann
| Nature Verified
Abstract Idiopathic inflammatory myopathies (IIMs) are autoimmune disorders defined by persistent muscle inflammation, fibrosis, and frequent resistance to current therapies. However, the mechanisms perpetuating disease activity despite immunosuppressive treatment remain elusive. Here, we describe a novel role for tissue-resident stromal cells, specifically fibro-adipogenic progenitors (FAPs), in sustaining skeletal muscle inflammation.
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Reprogramming of stroma-derived chemokine networks drives the loss of tissue organization in nodal B cell lymphoma

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By Felix Czernilofsky, Anna Mathioudaki, Lea Jopp-Saile, Raphael Lutz, Dominik Vonficht, Xi Wang, Tobias Roider, Marc-Andrea Baertsch, Michael Grau, Donnacha Fitzgerald, Jan Kosla, Nora Liebers, Peter-Martin Bruch, Diana Ordoñez-Rueda, Alexander Brobeil, Gunhild Mechtersheimer, Caroline Pabst, Carsten Müller-Tidow, Andreas Trumpp, Frank Neumann, Mathias Heikenwalder, Vladimir Benes, Wolfgang Huber, Jörg H. W. Distler, Georg Lenz, Hans Binder, Reiner Siebert, Garry P. Nolan, Moritz Gerstung, Judith B. Zaugg, Daniel Hübschmann, Simon J. Haas, Sascha Dietrich, Christina Schniederjohann, Harald Voehringer, Claus Rodemer, Henry Löffler-Wirth, Johannes Mammen, Marc Seifert
| Nature Verified
Abstract Lymph node (LN) function requires the organization of cells into higher-order spatial units. However, the principles governing LN architecture in health and disease remain poorly understood. Here, we used single-cell and spatial mapping to investigate the mechanisms directing immune cell organization in human LNs and its disruption in architecturally distinct lymphoma entities: indolent follicular lymphoma (FL) and aggressive diffuse large B cell lymphoma (DLBCL).
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Bispecific T cell engagers for treatment-refractory autoimmune connective tissue diseases - Nature Medicine

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By Christina Düsing, Andrea-Hermina Györfi, Ayla Nadja Stütz, Laura-Marie Lahu, Franca Deicher, Yi-Nan Li, Peter-Martin Bruch, Alexandru-Emil Matei, Alexandru Micu Verified, Tim Filla, Sarah Koziel, Alexander Sebastian Hölscher, Manuel Röhrich, Hanns-Martin Lorenz, Mareike Cramer, Gerald Antoch, Jörg Timm, Yousef Abusabha, Tobias Ruck, Bernhard Homey, Alexander Kreuter, Björn Buehring, Aleksandar Radujkovic, Claus Peter Heußel, Melanie Hagen, Ricardo Grieshaber-Bouyer, Georg Schett, Anna Brunn, Sascha Dietrich, Wolfgang Merkt, Jörg H. W. Distler
| Nature Verified
Abstract Autoimmune-mediated connective tissue diseases such as antisynthetase syndrome (ASyS) and systemic sclerosis (SSc) have a high unmet medical need. Here we report on treatment under compassionate use with the CD19×CD3 T cell engager (TCE) blinatumomab and the BCMA×CD3 TCE teclistamab in five patients with treatment-refractory ASyS and in five patients with treatment-refractory SSc, respectively.
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