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Highlights • Unbiased genetic approach reveals a role for yeast Swi/Snf in promoter repression • Swi/Snf represses promoters subject to upstream transcriptional readthrough • Repression is associated with Swi/Snf-dependent nucleosome remodeling • Swi/Snf-dependent repression regulates protein levels for LUTI-regulated genes Summary Alternative transcription start sites can affect transcript isoform diversity and translation levels.
Brar G.A. Yassour M. Friedman N. Regev A. Ingolia N.T. Weissman J.S. High-resolution view of the yeast meiotic program revealed by ribosome profiling. Science. 2012; 335: 552-557https://doi.org/10.1126/science.1215110 Chia M. Li C. Marques S. Pelechano V. Luscombe N.M. van Werven F.J. High-resolution analysis of cell-state transitions in yeast suggests widespread transcriptional tuning by alternative starts. Genome Biol.
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