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Saratchandra Singh Khumukcham on Muck Rack

Saratchandra Singh Khumukcham

As seen in: The Journal of Biological Chemistry
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Articles

HPIP and RUFY3 are non-canonical guanine exchange factors of Rab5 to regulate endocytosis-coupled focal adhesion turnover

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By Saratchandra Singh Khumukcham, Anita Kumari
| The Journal of Biological Chemistry Verified
Abstract While the role of endocytosis in focal adhesion turnover-coupled cell migration has been established in addition to its conventional role in cellular functions, the molecular regulators and precise molecular mechanisms that underlie this process remain largely unknown. In this study, we report that proto-oncoprotein HPIP (hematopoietic PBX interacting protein) localizes to focal adhesions as well as endosomal compartments along with RUFY3 and Rab5, an early endosomal protein.
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Hematopoietic PBX-interacting protein is a substrate and an inhibitor of the APC/C-Cdc20 complex and regulates mitosis by stabilizing cyclin B1

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By Saratchandra Singh Khumukcham, Vasudevarao Penugurti, Anita Kumari, P. S. Kesavan
| The Journal of Biological Chemistry Verified
Saratchandra Singh Khumukcham‡1, Venkata Subramanyam Kumar Samanthapudi‡1, Vasudevarao Penugurti‡1, Anita Kumari‡, P. S.
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Hematopoietic PBX-interacting protein is a substrate and an inhibitor of the APC/C-CDC20 complex and regulates mitosis by stabilizing cyclin B1

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By Saratchandra Singh Khumukcham, Vasudevarao Penugurti, Anita Kumari, P S Kesavan
| The Journal of Biological Chemistry Verified
Saratchandra Singh Khumukcham1, Venkata Subrahmanyam Kumar Samanthapudi2, Vasudevarao Penugurti1, Anita Kumari1, P S Kesavan3, Loka Reddy Velatooru1, Siva Reddy Kotla1, Aprotim Mazumder3 and Bramanandam Manavathi2* 1University of Hyderabad, India 2Biochemistry, University of Hyderabad, India 3TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research (TIFR) Hyderabad, India ↵* Corresponding author; email: manavbrahma{at}gmail.com Author contributions: S.S.K., V.P.,...
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