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SARFRAZ AHMED

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Articles

Scientists report new immune insights and targets into LRRK2 mutations in Parkinson's disease

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By SARFRAZ AHMED
| MSN Verified
Parkinson's disease (PD) is a debilitating and progressive neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra, a brain region essential for motor control. Clinically, it is marked by tremor, rigidity, bradykinesia and postural instability, symptoms that progressively erode independence and quality of life. Subscribe to our newsletter for the latest sci-tech news updates.
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Scientists report new immune insights and targets into LRRK2 mutations in Parkinson's disease

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By Roshni Jaffery, Yuhang Zhao, SARFRAZ AHMED, Sadie Harley
| Medical Xpress Verified
Conceptual illustration showing LRRK2-expressing immune cells, blood and CSF cytokines. Credit: Roshni Jaffery, Yuhang Zhao, Sarfraz Ahmed and Colleagues with help of AI Parkinson's disease (PD) is a debilitating and progressive neurodegenerative disorder caused by the loss of dopamine-producing neurons in the substantia nigra, a brain region essential for motor control.
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Soluble immune factor profiles in blood and CSF associated with LRRK2 mutations and Parkinson’s disease - npj Parkinson's Disease

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By Roshni Jaffery, Yuhang Zhao, SARFRAZ AHMED, Jackson G. Schumacher, Jae Eun Ahn, Leilei Shi, Yujia Wang, Yukun Tan, Ken Chen, Hussein Tawbi, Jian Wang, Michael A. Schwarzschild, Weiyi Peng
| Nature Verified
Abstract Mutations in LRRK2, a leading genetic cause of Parkinson’s disease (PD), are linked to immune dysregulation, but the immune profiles in the periphery and central nervous system (CNS) remain incompletely defined. This study utilized a large cohort of serum samples (n = 651) and matched CSF samples (n = 129) from LRRK2 mutation carriers and non-carriers, with and without PD, to assess immune regulators using Luminex immunoassay.
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